Dataset Information

Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity.

ABSTRACT: Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective of this study was to explore the effects of spermidine on intestinal morphology, metabolites, and microbial diversity in mice. We showed that 0.3 mmol/L of spermidine significantly promoted the growth of ileal villi (p < 0.05), and 3.0 mmol/L of spermidine significantly increased the body weight of mice and promoted the growth of jejunum villi (p < 0.05). The 16S rDNA sequencing results indicated that 3.0 mmol/L of spermidine affected the balance of the intestinal flora by increasing the abundance of intestinal Lactic acid bacteria and reducing the abundance of harmful bacteria (Turicibacter and Alistipes). Additionally, spermidine affects the levels of microbial metabolites such as succinic acid and Pantetheine. In summary, spermidine affects intestinal morphology and regulates intestinal flora and metabolites, and this study has provided a new understanding of spermidine's effects on the intestinal tract.

SUBMITTER: Jiang DM

PROVIDER: S-EPMC9919826 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity.

Jiang Dong-Mei DM Wang Ze-Long ZL Yang Jia-Di JD Wang Xin X Niu Chun-Yang CY Ji Cheng-Weng CW Ling Wei-Kang WK An Xiao-Guang XG Guo Yong-Ni YN Sun Qian Q Bai Lin L Li De-Bing DB Si Xiao-Hui XH Kang Bo B

Nutrients 20230201 3

Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective of this study was to explore the effects of spermidine on intestinal morphology, metabolites, and microbial diversity in mice. We showed that 0.3 mmol/L of spermidine significantly promoted the growth of ileal villi (<i>p</i> < 0.05), and 3.0 mmol/L of spermidine significantly increased the body weight of mice and promoted the growth of je ...[more]

PMID: 36771449

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Dataset Information

Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity.

Publications

Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity.

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