Vitamin D and Bone: A Story of Endocrine and Auto/Paracrine Action in Osteoblasts.

ABSTRACT: Despite its rigid structure, the bone is a dynamic organ, and is highly regulated by endocrine factors. One of the major bone regulatory hormones is vitamin D. Its renal metabolite 1α,25-OH2D3 has both direct and indirect effects on the maintenance of bone structure in health and disease. In this review, we describe the underlying processes that are directed by bone-forming cells, the osteoblasts. During the bone formation process, osteoblasts undergo different stages which play a central role in the signaling pathways that are activated via the vitamin D receptor. Vitamin D is involved in directing the osteoblasts towards proliferation or apoptosis, regulates their differentiation to bone matrix producing cells, and controls the subsequent mineralization of the bone matrix. The stage of d

SUBMITTER: van Driel M 

PROVIDER: S-EPMC9919888 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature