Ontology highlight
ABSTRACT:
SUBMITTER: Battisti UM
PROVIDER: S-EPMC9919951 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Battisti Umberto Maria UM Gao Chunixa C Akladios Fady F Kim Woonghee W Yang Hong H Bayram Cemil C Bolat Ismail I Kiliclioglu Metin M Yuksel Nursena N Tozlu Ozlem Ozdemir OO Zhang Cheng C Sebhaoui Jihad J Iqbal Shazia S Shoaie Saeed S Hacimuftuoglu Ahmet A Yildirim Serkan S Turkez Hasan H Uhlen Mathias M Boren Jan J Mardinoglu Adil A Grøtli Morten M
Nutrients 20230122 3
Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty liver disease (NAFLD), and inhibitors of this enzyme could represent a new therapeutic option. However, this breakthrough is complicated by selectivity issues since pyruvate kinase exists in four different isoforms. In this work, we report that ellagic acid (EA) and its derivatives, present in numerous fruits and vegetables, can inhibit PKL potently and selectively. Several polyphenolic analogues of EA were ...[more]