Design, Synthesis, Herbicidal Activity, and Structure-Activity Relationship Study of Novel 6-(5-Aryl-Substituted-1-Pyrazolyl)-2-Picolinic Acid as Potential Herbicides.

ABSTRACT: Picolinic acid and picolinate compounds are a remarkable class of synthetic auxin herbicides. In recent years, two new picolinate compounds, halauxifen-methyl (Arylex^TM active) and florpyrauxifen-benzyl (Rinskor^TM active), have been launched as novel herbicides. Using their structural skeleton as a template, 33 4-amino-3,5-dicholor-6-(5-aryl-substituted-1-pytazolyl)-2-picolinic acid compounds were designed and synthesized for the discovery of compounds with potent herbicidal activity. The compounds were tested for inhibitory activity against the growth of Arabidopsis thaliana roots, and the results demonstrated that the IC₅₀ value of compound V-7 was 45 times lower than that of the halauxifen-methyl commercial herbicide. Molecular docking anal

SUBMITTER: Feng T 

PROVIDER: S-EPMC9920234 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature