Green Synthesized sAuNPs as a Potential Delivery Platform for Cytotoxic Alkaloids.

ABSTRACT: The use of natural products as chemotherapeutic agents is well established. However, many are associated with undesirable side effects, including high toxicity and instability. Previous reports on the cytotoxic activity of pyrroloiminoquinones isolated from Latrunculid sponges against cancer cell lines revealed extraordinary activity at IC₅₀ of 77nM for discorhabdins. Their general lack of selectivity against the cancer and normal cell lines, however, precludes further development. In this study, extraction of a South African Latrunculid sponge produced three known pyrroloiminoquinone metabolites (14-bromodiscorhabdin C (5), Tsitsikammamine A (6) and B (7)). The assignment of the structures was established using standard 1D and 2D NMR experiments. To mitigat

SUBMITTER: Mubaiwa B 

PROVIDER: S-EPMC9920385 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature