Toxicity of the 3,4-Methylenedioxymethamphetamine and Its Enantiomers to Daphnia magna after Isolation by Semipreparative Chromatography.

ABSTRACT: MDMA (3,4-methylenedioxymethamphetamine) is a chiral psychoactive recreational drug sold in illicit markets as racemate. Studies on the impact of MDMA on aquatic organisms are scarce. While enantioselectivity in toxicity in animals and humans has been reported, none is reported on aquatic organisms. This study aimed to investigate the ecotoxicological effects of MDMA and its enantiomers in Daphnia magna. For that, enantiomers (enantiomeric purity > 97%) were separated by liquid chromatography using a homemade semipreparative chiral column. Daphnids were exposed to three concentrations of (R,S)-MDMA (0.1, 1.0 and 10.0 µg L^-1) and two concentrations of (R)- and (S)-enantiomers (0.1 and 1.0 µg L^-1) over the course of 8 days. Morphophysi

SUBMITTER: Costa AR 

PROVIDER: S-EPMC9920394 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature