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New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking.

ABSTRACT: The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity and some psychotropic properties of the new compounds were evaluated. The biological assays demonstrated that some of the studied compounds showed high anticonvulsant and psychotropic properties. The five most active compounds (7a, d, g, j, and m) contain a pyrano [3,4-c]pyridine cycle with a methyl group in the pyridine ring in their structures. Furthermore, molecular docking studies were performed, and their results are in agreement with experimental data.

SUBMITTER: Sirakanyan SN

PROVIDER: S-EPMC9920413 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking.

Sirakanyan Samvel N SN Spinelli Domenico D Petrou Anthi A Geronikaki Athina A Kartsev Victor G VG Hakobyan Elmira K EK Yegoryan Hasmik A HA Zuppiroli Luca L Zuppiroli Riccardo R Ayvazyan Armen G AG Paronikyan Ruzanna G RG Arakelyan Tatevik A TA Hovakimyan Anush A AA

Molecules (Basel, Switzerland) 20230117 3

The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity and some psychotropic properties of the new compounds were evaluated. The biological assays demonstrated that some of the studied compounds showed high anticonvulsant and psychotropic properties. The five most active compounds (7a, d, g, j, and m) contain a pyrano [3,4-c]pyridine cycle with a meth ...[more]

PMID: 36770592

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