DNA Base Excision Repair Intermediates Influence Duplex-Quadruplex Equilibrium.

ABSTRACT: Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex. These structures can exist within gene promoters, telomeric DNA, and regions of the genome frequently found altered in human cancers. DNA is also subject to hydrolytic and oxidative damage, and its local structure can influence the type of damage and its magnitude. Although the repair of endogenous DNA damage by the base excision repair (BER) pathway has been extensively studied in duplex DNA, substantially less is known about repair in non-duplex DNA structures. Therefore, we wanted to better understand the effect of DNA damage and repair on quadruplex structure. We first examined the effect of plac

SUBMITTER: Sowers ML 

PROVIDER: S-EPMC9920732 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature