Unknown

Dataset Information

0

Biosynthesized Silver Nanoparticles Using Morus alba (White Mulberry) Leaf Extract as Potential Antibacterial and Anticancer Agents.


ABSTRACT: In this study, we report the green synthesis of silver nanoparticles (AgNPs) from Morus alba or white mulberry leaf extract (MLE) and assess their antibacterial and anticancer potential. The GC-MS analysis of MLE confirmed the existence of phenolic compounds, serving as reducing, capping, and stabilizing agents in the biosynthesis of AgNPs. The MLE-AgNPs were spherical, with an average particle size of 20-44.5 nm and a face-centered cubic structure. EDX spectra confirmed the formation of AgNPs, and a negative zeta potential value (-14.5 mV) suggested their physicochemical stability. Excellent antibacterial activity was demonstrated by MLE-AgNPs against Acinetobacter baumannii strains with a MIC of 2 μg/mL, while good activity was observed against other Gram-negative (Escherichia coli and Salmonella typhimurium) and Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacteria with a MIC of 32 μg/mL. In vitro cytotoxic effects on MCF-7 (human breast cancer cells) and MCF-10A (normal human mammary epithelial cells) were investigated by the MTT assay. The half-maximal inhibitory concentrations (IC50) against MCF-7 cells were 18 and 33 μg/mL for MLE-AgNPs and MLE, respectively, with no effect on normal MCF-10A cells. Altogether, the results support the high antibacterial and anticancer potential of biosynthesized AgNPs by white mulberry leaf extract.

SUBMITTER: Kumkoon T 

PROVIDER: S-EPMC9920803 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Biosynthesized Silver Nanoparticles Using <i>Morus alba</i> (White Mulberry) Leaf Extract as Potential Antibacterial and Anticancer Agents.

Kumkoon Tipaporn T   Srisaisap Monrudee M   Boonserm Panadda P  

Molecules (Basel, Switzerland) 20230126 3


In this study, we report the green synthesis of silver nanoparticles (AgNPs) from <i>Morus alba</i> or white mulberry leaf extract (MLE) and assess their antibacterial and anticancer potential. The GC-MS analysis of MLE confirmed the existence of phenolic compounds, serving as reducing, capping, and stabilizing agents in the biosynthesis of AgNPs. The MLE-AgNPs were spherical, with an average particle size of 20-44.5 nm and a face-centered cubic structure. EDX spectra confirmed the formation of  ...[more]

Similar Datasets

2016-07-03 | E-GEOD-65839 | biostudies-arrayexpress
2016-01-01 | GSE65839 | GEO
| S-EPMC10448672 | biostudies-literature
2024-03-01 | GSE112338 | GEO
| S-EPMC4276671 | biostudies-other
| S-EPMC6795853 | biostudies-literature
| S-EPMC10804552 | biostudies-literature
2024-03-01 | GSE112333 | GEO
2024-03-01 | GSE112332 | GEO
| S-EPMC10143206 | biostudies-literature