Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a complex disorder with unexplained heritability. Interactions of genetic and environmental factors are thought to be crucial in COPD. So, we aim to examine interactions of the endothelial nitric oxide synthase (eNOS) and angiotensin converting enzyme (ACE) genes and cigarette smoking in COPD.

Methods

The eNOS G 894T and ACE ID variants were analyzed in 122 COPD patients and 200 controls from Serbia. The effect of the variants on COPD was assessed by logistic regression. Interactions between eNOS, ACE and cigarette smoking in COPD were evaluated using a case-control model. Interaction between the genes was analyzed in silico.

Results

No effect of the eNOS G 894T and ACE ID variants on COPD was found in our stu

SUBMITTER: Stankovic M 

PROVIDER: S-EPMC9920871 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature