Bioinformatics analyses of combined databases identify shared differentially expressed genes in cancer and autoimmune disease.

ABSTRACT:

Background

Inadequate immunity caused by poor immune surveillance leads to tumorigenesis, while excessive immunity due to breakdown of immune tolerance causes autoimmune genesis. Although the function of immunity during the onset of these two processes appears to be distinct, the underlying mechanism is shared. To date, gene expression data for large bodies of clinical samples are available, but the resemblances of tumorigenesis and autoimmune genesis in terms of immune responses remains to be summed up.

Methods

Considering the high disease prevalence, we chose invasive ductal carcinoma (IDC) and systemic lupus erythematosus (SLE) to study the potential commonalities of immune responses. We obtained gene expression data of IDC/SLE patients and normal controls from five IDC d

SUBMITTER: Sui Y 

PROVIDER: S-EPMC9921081 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature