Cell-cell communications shape tumor microenvironment and predict clinical outcomes in clear cell renal carcinoma.

ABSTRACT:

Background

Cell-cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless, comprehensive investigation of cell-cell communications in the ccRCC (Clear cell renal carcinoma) microenvironment and how this interplay affects prognosis still remains limited.

Methods

Intercellular communications were characterized by single-cell data. Firstly, we employed "CellChat" package to characterize intercellular communications across all types of cells in microenvironment in VHL mutated and non-mutated samples from 8 patients, respectively. And pseudotime trajectory analyses were performed with monocle analyses. Finally clinical prognosis and immunotherapy efficacy with

SUBMITTER: Chen LX 

PROVIDER: S-EPMC9921120 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature