Autoantibody-Abzymes with Catalase Activity in Experimental Autoimmune Encephalomyelitis Mice.

ABSTRACT: The exact mechanisms of the evolution of multiple sclerosis are still unknown. At the same time, the development in C57BL/6 mice of experimental autoimmune encephalomyelitis (EAE, simulating human multiple sclerosis) happens as a result of the violation of bone marrow hematopoietic stem cell differentiation profiles integrated with the production of toxic auto-antibodies splitting the basic myelin protein, myelin oligodendrocyte glycoprotein (MOG), histones, and DNA. It has been shown that IgGs from the plasma of healthy humans and autoimmune patients oxidize many different compounds due to their peroxidase (H₂O₂-dependent) and oxidoreductase (H₂O₂-independent) activities. Here, we first analyzed the changes in the relative catalase activity of I

SUBMITTER: Urusov AE 

PROVIDER: S-EPMC9921166 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature