Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors In Vivo.

ABSTRACT:

Objective

Osteosarcoma (OS) is a devastating primary bone tumor in dogs and humans with limited non-surgical treatment options. As the first completely non-invasive and non-thermal ablation technique, histotripsy has the potential to significantly improve the standard of care for patients with primary bone tumors.

Introduction

Standard of care treatment for primary appendicular OS involves surgical resection via either limb amputation or limb-salvage surgery for suitable candidates. Biological similarities between canine and human OS make the dog an informative comparative oncology research model to advance treatment options for primary OS. Evaluating histotripsy for ablating spontaneous canine primary OS will build a foundation upon which histotripsy can be translated clini

SUBMITTER: Ruger LN 

PROVIDER: S-EPMC9921194 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature