Linear multi-scale modeling of diffusion MRI data: A framework for characterization of oriented structures across length scales.

ABSTRACT: Diffusion-weighted magnetic resonance imaging (DW-MRI) has evolved to provide increasingly sophisticated investigations of the human brain's structural connectome in vivo. Restriction spectrum imaging (RSI) is a method that reconstructs the orientation distribution of diffusion within tissues over a range of length scales. In its original formulation, RSI represented the signal as consisting of a spectrum of Gaussian diffusion response functions. Recent technological advances have enabled the use of ultra-high b-values on human MRI scanners, providing higher sensitivity to intracellular water diffusion in the living human brain. To capture the complex diffusion time dependence of the signal within restricted water compartments, we expand upon the RSI approach to represent restricted water

SUBMITTER: Wichtmann BD 

PROVIDER: S-EPMC9921225 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature