Comprehensive shape analysis of the cortex in Huntington's disease.

ABSTRACT: The striatum has traditionally been the focus of Huntington's disease research due to the primary insult to this region and its central role in motor symptoms. Beyond the striatum, evidence of cortical alterations caused by Huntington's disease has surfaced. However, findings are not coherent between studies which have used cortical thickness for Huntington's disease since it is the well-established cortical metric of interest in other diseases. In this study, we propose a more comprehensive approach to cortical morphology in Huntington's disease using cortical thickness, sulcal depth, and local gyrification index. Our results show consistency with prior findings in cortical thickness, including its limitations. Our comparison between cortical thickness and local gyrification index undersc

SUBMITTER: Stoebner ZA 

PROVIDER: S-EPMC9921229 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature