Hippocampus shape characterization with 3D Zernike transformation in clinical Alzheimer's disease progression.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of dementia among older adults. Mild cognitive impairment (MCI) is considered a transitional phase between healthy cognitive aging and dementia. Progressive brain volume reduction/atrophy, particularly of the hippocampus, is associated with the transition from normal to MCI, and then to AD. We aimed to develop methods to characterize the shape of hippocampus and explore its potential as an imaging marker to monitor clinical AD progression. We implemented a 3D Zernike transformation to characterize the shape changes of hippocampus in 428 older subjects with high-quality T₁ -weighted volumetric brain scans from the Alzheimer's Disease Neuroimaging Initiative data set (151 normal, 258 MCI, and 19 AD).

SUBMITTER: Zhu DC 

PROVIDER: S-EPMC9921247 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature