Systematic analysis identifies XRCC4 as a potential immunological and prognostic biomarker associated with pan-cancer.

ABSTRACT:

Background

XRCC4 is a NHEJ factor identified recently that plays a vital role in repairing DNA double-stranded breaks. Studies have reported the associations between abnormal expression of XRCC4 and tumor susceptibility and radiosensitivity, but the potential biological mechanisms by which XRCC4 exerts effects on tumorigenesis are not fully understood. This study aimed to systematically investigate the role of XRCC4 across cancer types.

Methods

The TIMER, GTEX and Xiantao Academic database were used to interpret the expression of XRCC4. Genomic alterations and protein expression in human organic and tumor tissues were applied in cBioPortal and the Human Protein Atlas databases. Correlations between XRCC4 expression and immune and molecular subtypes were analyzed by using the

SUBMITTER: Yu Y 

PROVIDER: S-EPMC9921312 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature