Mechanistic Understanding of D-Glucaric Acid to Support Liver Detoxification Essential to Muscle Health Using a Computational Systems Biology Approach.
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ABSTRACT:
SUBMITTER: Ayyadurai VAS
PROVIDER: S-EPMC9921405 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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Mechanistic Understanding of D-Glucaric Acid to Support Liver Detoxification Essential to Muscle Health Using a Computational Systems Biology Approach.
Ayyadurai V A Shiva VAS Deonikar Prabhakar P Fields Christine C
Nutrients 20230201 3
Liver and muscle health are intimately connected. Nutritional strategies that support liver detoxification are beneficial to muscle recovery. Computational-in silico-molecular systems' biology analysis of supplementation of calcium and potassium glucarate salts and their metabolite D-glucaric acid (GA) reveals their positive effect on mitigation of liver detoxification via four specific molecular pathways: (1) ROS production, (2) deconjugation, (3) apoptosis of hepatocytes, and (4) β-glucuronida ...[more]
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