TAP1, a potential immune-related prognosis biomarker with functional significance in uveal melanoma.

ABSTRACT:

Background

TAP1 is an immunomodulation-related protein that plays different roles in various malignancies. This study investigated the transcriptional expression profile of TAP1 in uveal melanoma (UVM), revealed its potential biological interaction network, and determined its prognostic value.

Methods

CIBERSORT and ESTIMATE bioinformatic methods were used on data sourced from The Cancer Genome Atlas database (TCGA) to determine the correlation between TAP1 expression, UVM prognosis, biological characteristics, and immune infiltration. Gene set enrichment analysis (GSEA) was used to discover the signaling pathways associated with TAP1, while STRING database and CytoHubba were used to construct protein-protein interaction (PPI) and competing endogenous RNA (ceRNA) networks, re

SUBMITTER: Zhu R 

PROVIDER: S-EPMC9921415 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature