Osteocytic Sclerostin Expression as an Indicator of Altered Bone Turnover.

ABSTRACT: Renal osteodystrophy (ROD) is a complex and serious complication of chronic kidney disease (CKD), a major global health problem caused by loss of renal function. Currently, the gold standard to accurately diagnose ROD is based on quantitative histomorphometric analysis of trabecular bone. Although this analysis encompasses the evaluation of osteoblast and osteoclast number/activity, tfigurehe interest in osteocytes remains almost nihil. Nevertheless, this cell type is evidenced to perform a key role in bone turnover, particularly through its production of various bone proteins, such as sclerostin. In this study, we aim to investigate, in the context of ROD, to which extent an association exists between bone turnover and the abundance of osteocytes and osteocytic sclerostin expression in bo

SUBMITTER: Huybrechts Y 

PROVIDER: S-EPMC9921466 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature