Design and Synthesis of New Modified Flexible Purine Bases as Potential Inhibitors of Human PNP.

ABSTRACT: The great interest in studying the structure of human purine nucleoside phosphorylase (hPNP) and the continued search for effective inhibitors is due to the importance of the enzyme as a target in the therapy of T-cell proliferative diseases. In addition, hPNP inhibitors are used in organ transplant surgeries to provide immunodeficiency during and after the procedure. Previously, we showed that members of the well-known fleximer class of nucleosides are substrates of E. coli PNP. Fleximers have great promise as they have exhibited significant biological activity against a number of viruses of pandemic concern. Herein, we describe the synthesis and inhibition studies of a series of new fleximer compounds against hPNP and discuss their possible binding mode with t

SUBMITTER: Khandazhinskaya A 

PROVIDER: S-EPMC9921493 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature