Ontology highlight
ABSTRACT:
SUBMITTER: Kandinska MI
PROVIDER: S-EPMC9921785 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20230203 3
A series of novel 1-oxo-2,3,4-trisubstituted tetrahydroisoquinoline (THIQ) derivatives bearing other heterocyclic moieties in their structure were synthesized based on the reaction between homophthalic anhydride and imines. Initial studies were carried out to establish the anti-coronavirus activity of some of the newly obtained THIQ-derivatives against two strains of human coronavirus-229E and OC-43. Their antiviral activity was compared with that of their close analogues, piperidinones and thio ...[more]