Dietary Responses of Dementia-Related Genes Encoding Metabolic Enzymes.

ABSTRACT: The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer's disease, Parkinson's disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism-dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-ba

SUBMITTER: Parnell LD 

PROVIDER: S-EPMC9921944 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature