Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection.

ABSTRACT: Traditional macrocyclic molecules encode recognition sites in their structural backbones, which limits the variation of the recognition sites and thus, would restrict the adjustment of recognition properties. Here, we report a new oligoamide-based macrocycle capable of varying the recognition functional groups by post-synthesis modification on its structural backbone. Through six steps of common reactions, the parent macrocycle (9) can be produced in gram scale with an overall yield of 31%. The post-synthesis modification of 9 to vary the recognition sites are demonstrated by producing four different macrocycles (10-13) with distinct functional groups, 2-methoxyethoxyl (10), hydroxyl (11), carboxyl (12) and amide (13), respectively. T

SUBMITTER: Fan L 

PROVIDER: S-EPMC9921963 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature