A Novel Mechanism of Coactivator Recruitment by the Nurr1 Nuclear Receptor.

ABSTRACT: Nuclear receptors constitute one of the largest families of transcription factors that regulate genes in metazoans in response to small molecule ligands. Many receptors harbor two transactivation domains, one at each end of the protein sequence. Whereas the molecular mechanisms of transactivation mediated by the ligand-binding domain at the C-terminus of the protein are generally well established, the mechanism involving the N-terminal domain called activation function 1 (AF1) has remained elusive. Previous studies implicated the AF1 domain as a significant contributor towards the overall transcriptional activity of the NR4A family of nuclear receptors and suggested that the steroid receptor coactivators (SRCs) play an important role in this process. Here we show that a short segment withi

SUBMITTER: Daffern N 

PROVIDER: S-EPMC9922031 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature