Development and evaluation of a synthetic opioid targeted gas chromatography mass spectrometry (GC-MS) method.

ABSTRACT: As seized drug casework becomes increasingly complex due to the continued prevalence of emerging drugs, laboratories are often looking for new analytical approaches including developing methods for the analysis of specific compounds classes. Recent efforts have focused on the development of targeted gas chromatography mass spectrometry (GC-MS) confirmation methods to compliment the information-rich screening results produced by techniques like direct analysis in real time mass spectrometry (DART-MS). In this work, a method for the confirmation of synthetic opioids and related compounds was developed and evaluated. An 11-component test solution was used to develop a method that focused on minimizing overlapping retention time acceptance windows and understanding the influence of instrument

SUBMITTER: Sisco E 

PROVIDER: S-EPMC9922096 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature