Reducing toxic constituents of ginkgolic acid content and improving bioactive flavonoid content from Ginkgo biloba leaves by high-temperature pretreatment processing.

ABSTRACT: High-temperature pretreatment was developed in this article to remove the main toxic constituents of ginkgolic acids (GAs) from Ginkgo biloba leaves (GBLs) and improve the bioactive flavonoid content by water extraction. To optimize the effects of high-temperature pretreatment process parameters on removing toxic GAs to a limited level and improving the content of bioactive flavonoids, a Box-Behnken design (BBD) combined with response surface methodology (RSM) was also conducted. The results showed that the content of GAs could be reduced to 4.11 ppm and the highest content of flavonoids could reach 3.51% under the optimized conditions of high-temperature pretreatment process of 177°C with water extraction at 96°C at a liquid-to-solid ratio of 56:1. The content of toxic GAs substant

SUBMITTER: Zhao F 

PROVIDER: S-EPMC9922130 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature