Major depressive disorders increase the susceptibility to self-reported infections in two German cohort studies.

ABSTRACT:

Introduction

In several claims-based studies, major depressive disorder (MDD) has been associated with increased risk of hospitalization due to acute infections. It remains unclear if this is a causal effect, and if it generalizes to an increased susceptibility to infections.

Methods

We used data of the BiDirect (n = 925) and the HaBIDS (n = 1007) cohort studies to estimate the effect of MDD on self-reported infections, which were assessed with identical infection susceptibility questionnaires in both studies. We used the Center for Epidemiologic Studies Depression Scale (CES-D) to examine if there was a dose-response relationship between depressive symptom severity and self-reported infections.

Results

BiDirect participants with MDD diagnosis (48%) had a higher risk

SUBMITTER: Elpers H 

PROVIDER: S-EPMC9922209 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature