Cognitive changes are associated with increased blood-brain barrier leakage in non-brain metastases lung cancer patients.

ABSTRACT: To explore the relationship between cognitive function and blood-brain barrier leakage in non-brain metastasis lung cancer and healthy controls. 75 lung cancers without brain metastasis and 29 healthy controls matched with age, sex, and education were evaluated by cognitive assessment, and the Patlak pharmacokinetic model was used to calculate the average leakage in each brain region according to the automated anatomical labeling atlas. After that, the relationships between cognitive and blood-brain barrier leakage were evaluated. Compared with healthy controls, the leakage of bilateral temporal gyrus and whole brain gyrus were higher in patients with lung cancers (P < 0.05), mainly in patients with advanced lung cancer (P < 0.05), but not in patients with early lung cancer (P > 0.05). The

SUBMITTER: Zhang DF 

PROVIDER: S-EPMC9922230 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature