Mechanism of arterial injury exacerbated by hyperhomocysteinemia in spontaneously hypertensive rats.

ABSTRACT: Hypertension associated with hyperhomocysteinemia (HHcy) accounts for 75% of hypertension in China. HHcy plays a synergistic role with hypertension in vascular injury and significantly increases the incidence of cardiovascular and cerebrovascular diseases. The present study aimed to explore the molecular mechanism of HHcy-induced arterial injury in hypertension. Spontaneously hypertensive rats (SHR) were injected intraperitoneally with DL-homocysteine (Hcy) to construct the model of hypertension associated with HHcy (HHcy + SHR). Biological network was employed to identify the material basis of arterial injury in hypertension associated with HHcy. The prediction molecules in oxidative stress and inflammation pathways were experimentally verified by quantitative real-time polymerase chain r

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9922276 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature