Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms.

ABSTRACT: Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in the regulatory network generates autonomous circadian oscillations in eukaryotic systems. In comparison, the circadian clock of cyanobacteria is controlled by a strong positive feedback loop. Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. What makes a circadian oscillatory network robust to extrinsic noise is unclear. We investigated four basic circadian oscillators with negative, positive, and combinations of positive and negativ

SUBMITTER: Chakravarty S 

PROVIDER: S-EPMC9922291 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature