Ischemic wound revascularization by the stromal vascular fraction relies on host-donor hybrid vessels.

ABSTRACT: Nonhealing wounds place a significant burden on both quality of life of affected patients and health systems. Skin substitutes are applied to promote the closure of nonhealing wounds, although their efficacy is limited by inadequate vascularization. The stromal vascular fraction (SVF) from the adipose tissue is a promising therapy to overcome this limitation. Despite a few successful clinical trials, its incorporation in the clinical routine has been hampered by their inconsistent results. All these studies concluded by warranting pre-clinical work aimed at both characterizing the cell types composing the SVF and shedding light on their mechanism of action. Here, we established a model of nonhealing wound, in which we applied the SVF in combination with a clinical-grade skin substitute. We

SUBMITTER: Vuerich R 

PROVIDER: S-EPMC9922297 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature