[¹⁸F]Sodium fluoride PET-MRI detects increased metabolic bone response to whole-joint loading stress in osteoarthritic knees.

ABSTRACT:

Objective

Altered joint function is a hallmark of osteoarthritis (OA). Imaging techniques for joint function are limited, but [¹⁸F]sodium fluoride (NaF) PET-MRI may assess the acute joint response to loading stresses. [¹⁸F]NaF PET-MRI was used to study the acute joint response to exercise in OA knees, and compare relationships between regions of increased uptake after loading and structural OA progression two years later.

Methods

In this prospective study, 10 participants with knee OA (59 ± 8 years; 8 female) were scanned twice consecutively using a PET-MR system and performed a one-legged squat exercise between scans. Changes in tracer uptake measures in 9 bone regions were compared between knees that did and did not exercise with a mixed-effects model

SUBMITTER: Watkins LE 

PROVIDER: S-EPMC9922526 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature