Paternal occupational exposures and infant congenital heart defects in the Japan Environment and Children's Study.

ABSTRACT:

Background

Few prospective studies have investigated the association between paternal occupational exposures and risk of infant congenital heart defects (CHDs). We investigated the associations between paternal occupational exposures, frequency of use, and concurrent or sequential exposure to a mixture of compounds and the risk of infant CHDs.

Methods

Our study examined 28,866 participants in the Japan Environment and Children's Study. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) associated with paternal occupational exposures during the 3 months until pregnancy was noticed after adjustment for potential confounding factors of the infant CHDs. CHD diagnosis was ascertained from medical record.

Results

In total,

SUBMITTER: Hayama-Terada M 

PROVIDER: S-EPMC9922566 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature