Sepsis as an independent risk factor in atrial fibrillation and cardioembolic stroke.

ABSTRACT:

Background

Electrolyte balance is an important factor to sustain the homeostasis of human body environment and in sepsis pathogenesis. Many current cohort-based studies have already revealed that electrolyte disorder may intensify sepsis and induce stroke. However, the corresponding randomized controlled trials did not show that electrolyte disorder in sepsis has a harmful effect on stroke.

Objectives

The aim of this study was to examine the association of genetically sepsis-derived electrolyte disorder with stroke risk using meta-analysis and Mendelian randomization.

Results

In four studies (182,980 patients), electrolyte disorders were compared with stroke incidence in patients with sepsis. The pooled odds ratio (OR) of stroke is 1.79 [95% confidence interval (CI):

SUBMITTER: Leng Y 

PROVIDER: S-EPMC9922695 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature