The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naive schizophrenia.

ABSTRACT:

Background

Our previous study has shown the cingulate cortex abnormalities in first-episode drug naïve (FEDN) schizophrenia patients with comorbid depressive symptoms. However, it remains largely unknown whether antipsychotics may induce morphometric change in cingulate cortex and its relationship with depressive symptoms. The purpose of this study was to further clarify the important role of cingulate cortex in the treatment on depressive symptoms in FEDN schizophrenia patients.

Method

In this study, 42 FEDN schizophrenia patients were assigned into depressed patients group (DP, n = 24) and non-depressed patients group (NDP, n = 18) measured by the 24-item Hamilton Depression Rating Scale (HAMD). Clinical assessments and anatomical images were obtained from al

SUBMITTER: Shen H 

PROVIDER: S-EPMC9922813 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature