Modeling the heterogeneity of sodium and calcium homeostasis between cortical and hippocampal astrocytes and its impact on bioenergetics.

ABSTRACT: Emerging evidence indicates that neuronal activity-evoked changes in sodium concentration in astrocytes Na _a represent a special form of excitability, which is tightly linked to all other major ions in the astrocyte and extracellular space, as well as to bioenergetics, neurotransmitter uptake, and neurovascular coupling. Recently, one of us reported that Na _a transients in the neocortex have a significantly higher amplitude than those in the hippocampus. Based on the extensive data from that study, here we develop a detailed biophysical model to further understand the origin of this heterogeneity and how it affects bioenergetics in the astrocytes. In addition to closely fitting the observed experimental Na _a changes under different cond

SUBMITTER: Thapaliya P 

PROVIDER: S-EPMC9922870 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature