Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila.

ABSTRACT: Deficiencies in the human dystrophin glycoprotein complex (DGC), which links the extracellular matrix with the intracellular cytoskeleton, cause muscular dystrophies, a group of incurable disorders associated with heterogeneous muscle, brain and eye abnormalities. Stresses such as nutrient deprivation and aging cause muscle wasting, which can be exacerbated by reduced levels of the DGC in membranes, the integrity of which is vital for muscle health and function. Moreover, the DGC operates in multiple signaling pathways, demonstrating an important function in gene expression regulation. To advance disease diagnostics and treatment strategies, we strive to understand the genetic pathways that are perturbed by DGC mutations. Here, we utilized a Drosophila model to investigate the transcriptom

SUBMITTER: Carney TD 

PROVIDER: S-EPMC9922874 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature