Polygonum tinctorium leaf extract ameliorates high-fat diet-induced intestinal epithelial damage in mice.

ABSTRACT: Dietary fat strongly influences the intestinal mucosal barrier, which protects against invading pathogenic bacteria. A high-fat diet (HFD) compromises the integrity of epithelial tight junctions (TJs) and reduces mucin production, leading to intestinal barrier disruption and metabolic endotoxemia. It has been shown that the active constituents of indigo plants can protect against intestinal inflammation; however, their protective role in HFD-induced intestinal epithelial damage remains unknown. The present study aimed to investigate the effects of Polygonum tinctorium leaf extract (indigo Ex) on HFD-induced intestinal damage in mice. Male C57BL6/J mice were fed a HFD and injected intraperitoneally with either indigo Ex or phosphate-buffered saline (PBS) for 4 weeks. The expression l

SUBMITTER: Kawaguchi S 

PROVIDER: S-EPMC9922942 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature