Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis.

ABSTRACT:

Objective

The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis.

Design

Electronic databases were systematically searched for studies on the oral microbiome in OSCC published before December 2021. Qualitative assessments of compositional variations at the phylum level were performed. The meta-analysis on abundance changes of bacteria genera was performed via a random-effects model.

Results

A total of 18 studies involving 1056 participants were included. They consisted of two categories of studies: 1) case-control studies (n = 9); 2) nine studies that compared the oral microbiome between cancerous tissues and paired paracancerous tissues.

SUBMITTER: Yu X 

PROVIDER: S-EPMC9922960 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature