GFR Variability, Survival, and Cardiovascular Events in Older Adults.

ABSTRACT:

Rationale & objective

Variability in estimated glomerular filtration rate (eGFR) over time is often observed, but it is unknown whether this variation is clinically important. We investigated the association between eGFR variability and survival free of dementia or persistent physical disability (disability-free survival) and cardiovascular disease (CVD) events (myocardial infarction, stroke, hospitalization for heart failure, or CVD death).

Study design

Post hoc analysis.

Setting & participants

12,549 participants of the ASPirin in Reducing Events in the Elderly trial. Participants were without documented dementia, major physical disability, previous CVD, and major life-limiting illness at enrollment.

Predictors

eGFR variability.

Outcomes

Disability-fre

SUBMITTER: Fravel MA 

PROVIDER: S-EPMC9922964 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature