Severity-dependent functional connectome and the association with glucose metabolism in the sensorimotor cortex of Parkinson's disease.

ABSTRACT: Functional MRI studies have achieved promising outcomes in revealing abnormal functional connectivity in Parkinson's disease (PD). The primary sensorimotor area (PSMA) received a large amount of attention because it closely correlates with motor deficits. While functional connectivity represents signaling between PSMA and other brain regions, the metabolic mechanism behind PSMA connectivity has rarely been well established. By introducing hybrid PET/MRI scanning, the current study enrolled 33 advanced PD patients during medication-off condition and 25 age-and-sex-matched healthy controls (HCs), aiming to not only identify the abnormal functional connectome pattern of the PSMA, but also to simultaneously investigate how PSMA functional connectome correlates with glucose metabolism. We calcu

SUBMITTER: Zang Z 

PROVIDER: S-EPMC9922997 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature