Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse.

ABSTRACT: Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A subunit. However, the ASIC2A and ASIC2B subunits are known to interact with ASIC1A, and their potential roles in drugs of abuse have not yet been investigated. Therefore, we tested the effects of disrupting ASIC2 subunits in mice exposed to drugs of abuse. We found conditioned place preference (CPP) to both cocaine and morphine were increased in Asic2 ^-/- mice, which is similar to what was observed in Asic1a ^-/- mice. Because nucleus accumbens core (NAcc) is an important site of ASIC1A action, w

SUBMITTER: Fuller MJ 

PROVIDER: S-EPMC9923001 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature