Expression and significance of m6A-RNA-methylation in oral cancer and precancerous lesion.

ABSTRACT:

Background

Oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) are a series of related pathologic and molecular events involving simple epithelial hyperplasia, mild to severe dysplasia and canceration. N6-methyladenosine RNA methylation, as the most common modification of both coding mRNA and non-coding ncRNA in eukaryotes, participates in the regulation of the occurrence and development of various malignant tumors in human. However, its role in oral epithelial dysplasia (OED) and OSCC remain unclear.

Materials and methods

In this study, multiple public databases were used for bioinformatics analysis of 23 common m6A methylation regulators in head and neck squamous cell carcinoma (HNSCC). Protein expressions of IGF2BP2 and IGF2BP3 were verifi

SUBMITTER: Qin Z 

PROVIDER: S-EPMC9923020 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature