The inflammatory proteome, obesity, and medical weight loss and regain in humans.

ABSTRACT:

Objective

Weight regain occurs after medical weight loss via mechanisms of post-weight-loss "metabolic adaptation." The relationship of inflammatory proteins with weight loss/regain was studied to determine a role for inflammation in metabolic adaptation.

Methods

Seventy-four proteins central to inflammation and immune regulation (Olink) were analyzed in plasma from up to 490 participants in a trial of medical weight-loss maintenance. Cross-sectional and longitudinal associations of proteins with weight were measured using linear and mixed effects regression models and t testing, with replication in the Framingham Heart Study.

Results

Broad changes in the inflammatory proteome were observed among the study cohort (60% women, 35% African American) with initial weight l

SUBMITTER: Perry AS 

PROVIDER: S-EPMC9923277 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature