An allozyme polymorphism is associated with a large chromosomal inversion in the marine snail Littorina fabalis.

ABSTRACT: Understanding the genetic targets of natural selection is one of the most challenging goals of population genetics. Some of the earliest candidate genes were identified from associations between allozyme allele frequencies and environmental variation. One such example is the clinal polymorphism in the arginine kinase (Ak) gene in the marine snail Littorina fabalis. While other enzyme loci do not show differences in allozyme frequencies among populations, the Ak alleles are near differential fixation across repeated wave exposure gradients in Europe. Here, we use this case to illustrate how a new sequencing toolbox can be employed to characterize the genomic architecture associated with historical candidate genes. We found that the Ak alleles differ by nine nonsy

SUBMITTER: Le Moan A 

PROVIDER: S-EPMC9923470 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature