Impact of incremental initiation of haemodialysis on mortality: a systematic review and meta-analysis.

ABSTRACT:

Background

Incremental haemodialysis initiation entails lower sessional duration and/or frequency than the standard 4 h thrice-weekly approach. Dialysis dose is increased as residual kidney function (RKF) declines. This systematic review evaluates its safety, efficacy and cost-effectiveness.

Methods

We searched MEDLINE, EMBASE, CINAHL and the Cochrane Library databases from inception to 27 February 2022. Eligible studies compared incremental haemodialysis (sessions either fewer than three times weekly or of duration <3.5 h) with standard treatment. The primary outcome was mortality. Secondary outcomes included treatment-emergent adverse events, loss of RKF, quality of life and cost effectiveness. The study protocol was prospectively registered. Risk of bias assessment used t

SUBMITTER: Caton E 

PROVIDER: S-EPMC9923704 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature