The direct effect of fibroblast growth factor 23 on vascular smooth muscle cell phenotype and function.

ABSTRACT:

Background

In chronic kidney disease (CKD) patients, increased levels of fibroblast growth factor 23 (FGF23) are associated with cardiovascular mortality. The relationship between FGF23 and heart hypertrophy has been documented, however, it is not known whether FGF23 has an effect on vasculature. Vascular smooth muscle cells VSMCs may exhibit different phenotypes; our hypothesis is that FGF23 favours a switch from a contractile to synthetic phenotype that may cause vascular dysfunction. Our objective was to determine whether FGF23 may directly control a change in VSMC phenotype.

Methods

This study includes in vitro, in vivo and ex vivo experiments and evaluation of patients with CKD stages 2-3 studying a relationship between FGF23 and vascular dysfunction.

Results

In

SUBMITTER: Vergara N 

PROVIDER: S-EPMC9923714 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature