Inflammatory Bowel Disease Risk Variants Are Associated with an Increased Risk of Skin Cancer.

ABSTRACT:

Background

Inflammatory bowel disease is associated with an increased risk of skin cancer. The aims of this study were to determine whether IBD susceptibility variants are also associated with skin cancer susceptibility and if such risk is augmented by use of immune-suppressive therapy.

Methods

The discovery cohort included participants in the UK Biobank. The validation cohort included participants in the Michigan Genomics Initiative. The primary outcome of interest was skin cancer, subgrouped into nonmelanoma skin cancers (NMSC) and melanoma skin cancers (MSC). Multivariable logistic regression with matched controls (3 controls:1 case) was performed to identify genomic predictors of skin malignancy in the discovery cohort. Variants with P < .05 were tested for replication i

SUBMITTER: Cushing KC 

PROVIDER: S-EPMC9924040 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature